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To validate the feasibility of our AD-related pathway-gene network-based method for identifying natural products for AD, we conducted a thorough search of PubMed, Web of Science, and Scopus to determine the research status of the 177 natural products

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This is partly a result of insulins effects on hepatic GHR expression, and partly a post-receptor signaling effect as unraveled by extensive animal studies (reviewed in (60)