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The strategic user turns to nicotine for a pick-me-up, and the dependent user relies on it to just feel normal. Nicotine, as a stimulant, primarily affects the users cardiovascular system, but exactly how it impacts athletes during play needs to be studied further, says Mndel, who worked on the nine-year nicotine study

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Fermentation: The cured leaves are fermented to develop their flavor further, reducing harshness and creating a smooth smoking experience

These differences could arise from the 20 mg/ml cap on nicotine concentration in e-cigarettes in the EU, which may have undermined how pod e-cigarettes with nicotine salts allow users to vape high nicotine concentrations without irritation to the throat 3,19