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This process upregulates the expression of antioxidant enzymes including glutathione peroxidase (GPX), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1), thereby enhancing cellular capacity to eliminate oxidative damage (Yao and Liu, 2022)

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In this enzymatic reaction, GSH becomes oxidized to GSSG, which is recycled back to GSH by the NADPH-dependent GSSG reductase as shown in Figure 2

As observed by Corachn et al., Vitamin D inhibits the Wnt/-catenin and TGF pathways, reducing proliferation and extracellular matrix formation, in different molecular subtypes of uterine myomas (MED12-mutated and wild-type human tumors) [83]