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Remodeling the immune environment of the wound beds, especially polarizing macrophages to the M2-phenotype with a sustained anti-inflammatory effect, is necessary to promote healing

Indirect calorimetry To assess possible changes in metabolic parameters, mice were measured by indirect calorimetry using an open respirometry system (TSE PhenoMaster, TSE Systems)

Chemical Sensitivities: Enhanced liver conjugation pathways allow the body to process and excrete environmental toxins, heavy metals, and medications more efficiently, potentially reducing severe reactions to everyday chemical exposures

Betaine can increase the expression of fibroblast growth factor 21 in the liver (Reference Zeisel38) , thereby enhancing the oxidation of fatty acids

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