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Subcutaneous protocols achieve peak plasma levels within 24 hours and maintain therapeutic concentrations for 1216 hours, which supports once-daily dosing
Despite poor correlation with AUC, TDM by measuring full blood concentration 12 (C12)- or 24 (C24) hours after administration is most commonly used and currently state of the art (63) and C2 plus C10 for AUC0-24 (64), but have not yet gained acceptance in clinical practice, mainly due to practical reasons (65)
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