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Advantage : Neither (tie) Weight Loss Efficacy# CagriSema : REDEFINE 1 Phase 3 demonstrated 20.4% mean weight loss at 68 weeks

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The gap between the marketed mechanism (localized IGF-1 receptor activation driving hyperplasia) and lived experience (systemic effects including lethargy, joint pain, and unpredictable blood glucose swings) is what makes community discussion essential

Until recently, fascia was largely ignored in knee OA research, but new discoveries in the 2020s show that fascial structures play critical roles in knee pain, stiffness, biomechanics, and knee OA progression