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Nature 535 , 111116 (2016)

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Safety outcomes assessed included baseline and peak activated partial thromboplastin time, incidence of epistaxis, blood-tinged sputum, pulmonary bleeding, gastrointestinal hemorrhage, major bleeding, heparin-induced thrombocytopenia, anaphylaxis, bronchospasm, and respiratory deterioration during or immediately after administration of inhaled nebulised HABIT or any other adverse events

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Compared with the control group, this group also exhibited the significantly improved activities of SOD, CAT, and GSH-Px, along with significantly upregulated expression of the antioxidant genes SOD1 and NRF2