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Chimienti, F., Devergnas, S., Favier, A

It is very difficult to make recommendations or draw valid conclusions on the effectiveness of oral supplements and systemic drugs in the treatment of skin aging, as most of the evidence is based on small, single-center studies with short follow-up periods (mostly 24 months), predominantly female samples, and use of heterogeneous methodologies and evaluation criteria

The p53/p21 and p16/Rb (retinoblastoma) axes are the two central signaling pathways involved in senescence regulation

August 28, 2023

Although the impact of such feed-forward connections is currently unknown, we postulate that these speculative multi-phasic responses in thalamus evoked by cerebellar nuclei stimulation aid to stop thalamo-cortical oscillations by increasing the excitatory drive onto thalamic relay neurons and by desynchronizing thalamo-cortical activity