UbiBrowser 2.0 database indicated that NEDD4, VHL, SMURF1, and SIAH2
Correia C, Coutinho AM, Diogo L, Grazina M, Marques C, Miguel T, et al
All experiments were approved by the Ethics Committee of the Plastic Surgery Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Their secretion of matrix metalloproteinases (MMPs), serine proteases, and cathepsins disrupts the endothelial basement membranes, degrades extracellular matrix components, including collagen, and facilitates the migration of tumor and stromal cells, ultimately promoting tumor angiogenesis and metastasis ( Dixon defined ferroptosis as a unique type of controlled cell death in 2012, based on its iron-dependent mechanism and fundamental deviations from apoptotic pathways ( Figure 3 )