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Preclinical studies using animal models or neuronal cell cultures for conditions such as Parkinson's or Alzheimer's disease often measure tissue-specific GSH levels and the GSH/GSSG ratio as key biomarkers of oxidative damage

Conclusions This body of work demonstrates the development and validation of assays using a tissue chip platform for high-content drug screening and the successful discovery and in vivo validation of candidate radioprotective drugs with non-antioxidant primary modes of action

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Interestingly, a small study investigating moderate/high alcohol consumption of 375ml white wine per day (42g alcohol) for 1 month reported that alcohol consumption did not increase the average baseline homocysteine concentration but a very high level of folic acid supplementation along with alcohol ingestion was effective at lowering homocysteine ( Rajdl et al, 2016)

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