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Pb II - and Cd II -Sensing MerRs Early studies of a number of canonical metal-sensing MerRs revealed that a major determinant of metal selectivity was the specific arrangement of residues (usually Cys or His) in the inducer-binding sites largely localized to a metal binding loop (MBL), 323 with a preferred coordination geometry for a monovalent vs a divalent metal ion

however, their long-term medical efficacy is uncertain, and studies are generally limited by small sample sizes and methodological diversity [52]

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