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Acknowledgements We thank the Center for Studies in Microscopy and Image Processing (NEMPI) at the School of Medicine of the Federal University of Cear (UFC) for all histology and digital image services
The GSH adducts formed in such reactions are in most cases less toxic than the unconjugated substrates, and the GSH conjugates can in many cases be efficiently removed from the cells by multidrug resistance protein (Mrp) mediated export (Figure 2) (Dringen et al
The bodys master intracellular antioxidant Most abundant antioxidant inside cells
Both IGF-1 splice variants are incredibly fragile biological proteins
Astrocytic reactivity reflects activation of complex molecularly defined programmes which define remodelling of biochemical, morphological, metabolic, and physiological properties of astroglia leading to an upregulation or loss of homoeostatic cascades, or in gain of new protective or regenerative functions
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