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Women are more susceptible than men to statin-induced decrements in DHA -3 fatty acid and mitochondrial complex activity Our studies in mice indicated that sex-biased reduction in DHA levels after statin treatment is a determinant of adverse effects in females, and that fish oil complementation prevents glucose intolerance, reduced oxidative tone, and impaired mitochondrial activity

438 There is growing evidence indicating that cytosolic NADPH is one of the effectory metabolic coupling factors, a variety of critical intermediates and cofactors involved in the GSIS

Rivera-RodriguezLPardo-DazEMoreno-EspinosaSScheffler-MendozaSRuiz-OntiverosMAGarrido-GarcaLMet al

Ji, S., Wang, L

10.1210/jcem-60-3-513 J