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Experimentally this is measured by comparing the Area-Under-the-Curve (AUC) of the drug when serial measurements of plasma concentration are made following oral administration compared to i.v

Understanding PACE

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N-acetylcysteine enhances the conjugation and excretion of N-acetyl-p-quinone imine, and when administered after liver injury has developed, N- acetylcysteine acts by antioxidant and anti- inflammatory mechanisms

doi:10.1002/mrm.1910250110 106. Rubenstein, J