This combination has not been formally studied in clinical trials, but the biological rationale is sound based on what we know about both modalities
Cross-talks and perspectives Both GSH and Pro, with molecular formula C 10 H 17 N 3 O 6 S and C 5 H 9 NO 2 , respectively, belong to the glutamate or -ketoglutarate family and originate from a common precursor L-glutamate (Moat et al., 2014) and Pro (Lehmann et al., 2012)
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The Gene Modulation Argument The Broad Institute Connectivity Map analysis cited by Campbell et al
Consistently, glycine supplementation upregulated GSH formation (enzymatic activities of GSH reductase, -glutamylcysteine synthetase, and GSH synthetase) in the liver and proximal intestine