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doi: 10.3390/pathogens13070565

96 Additionally, AMPK activation by reduced ATP levels maintains NADPH through inhibiting NADPH consumption in fatty-acid synthesis and enhancing NADPH production from fatty-acid oxidation instead of PPP to inhibit cell death

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Surprisingly, another study showed that diabetes-related cardiovascular autonomic damage is first manifested in the vagus nerve (106), which may involve a ferroptosis-mediated overall decrease in parasympathetic tone, ultimately leading to over-activation of the sympathetic nerve and the worsening development of metabolic complications

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