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6.4 D-gel/LPS-induced TNF--mediated liver failure model Lipopolysaccharide (LPS) is a molecule that is present in the outer membrane of gram-negative bacteria and can activate Kupffer cells (198200), triggering the secretion of multiple inflammatory mediators (200, 201), and the coadministration of 300 mg/kg D-Gal dramatically increased rodent susceptibility to LPS, resulting in extensive liver injury and cell death (202)

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Blood Transfus 10 , s12s18 (2012)

Geographic variations in diagnostic delay reveal important system-level factors