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Semaglutide mimics GLP-1, an incretin released by the intestine after a meal, which slows gastric emptying and stimulates insulin secretion

Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells

This triggers GH release through a separate signaling cascade