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This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome

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Mechanism of Action 5-Amino-1MQ functions as an inhibitor of nicotinamide N-methyltransferase (NNMT) , an enzyme responsible for the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor