Mechanistically, SYVN1 binds to HMGB1, promoting its ubiquitination and degradation and alleviating SCIRI in rats by downregulating HMGB1 and activating the Nrf2/HO-1 pathway
Nat Rev Mol Cell Biol 21 , 101118 (2020)
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These defects lead to a profound dysregulation of other NAD-dependent genes, such as SIRTs, PARPs, and acetylated proteins in the Sirt3-Foxo4 axis, and suppression of the TCA cycle
Sekizawa J (2008) Low-dose effects of bisphenol A: a serious threat to human health
