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Finally, oxidative stress itself can promote non-enzymatic synthesis of KYNA from KYN or indole-3-pyruvic acid, independent of KAT activity [169]

Behrens TE Neuron 83(5):10191039 Haider S, Tabassum S (2018) Impact of 1-day and 4-day MWM training techniques on oxidative and neurochemical profile in rat brain: a comparative study on learning and memory functions