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J Gerontol B Psychol Sci Soc Sci

1721 Cotinine is also metabolized by CYP2A6 to form trans -3-hydroxycotinine (3HC) and, like nicotine, can undergo conversion by UGT2B10-mediated glucuronidation to form cotinine glucuronide (Cot-Gluc) 22 or oxidation by CYPs 2C19 and 2A6 to form cotinine N-oxide (COX)