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Importantly, KRAS-dependent NSCLC cells that were hypersensitive to LDHB/SLC7A11 inhibition (A549, H460, H2122, H838, H2009, KP) exhibited high levels of NRF2 or NRF2 score based on prior studies [57, 58], whereas the outliers (H358, H23, and Calu-1), in which LDHB KD failed to sensitize the cells to Erastin or RSL3, are characterized by low NRF2 levels

It has been shown to influence the expression of genes involved in angiogenesis (e.g., egr-1), stabilize endothelial integrity, and facilitate the recruitment of fibroblasts to injury sites 4

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[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Prasun P, LoPiccolo MK, Ginevic I, et al

They are all closely dependant on each other so the absence of one will critically effect the activity of all others