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In particular, the relevance of the ATB 0,+ -mediated carnitine transport, in patients with PCD, may be explained considering that this protein is highly expressed in the intestine (Figure 2)

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47 In addition to this, we have previously identified that inhibition of TGF 1 can lead to increased expression of the hedgehog transcription factor Gli1

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In some embodiments, the needle gauge is about 18 gauge, about 19 gauge, about 20 gauge, about 21 gauge, about 22 gauge, about 23 gauge, about 24 gauge, about 25 gauge, about 26 gauge, about 27 gauge, about 28 gauge, about 29 gauge, or about 30 gauge