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Free Radic Biol Med 37(8):11911202

Quickstart Highlights DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (9 amino acids) first isolated from rabbit brain tissue and studied for its proposed effects on sleep architecture and stress modulation [1] [2]

However, only ~ 50% patients with opioid-induced constipation exhibit satisfactory response to PAMORA-based clinical management strategies targeting MORs in the enteric nervous system, and we observed that naloxegol could only partially alleviate morphine-induced constipation

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Documented doses are animal-only: ~1.44-2.88 mg/kg oral in mice