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These data show the low reactivity of the free depsipeptides and confirm the chemical stability of cereulide as reported earlier 20,21,22

The 1st cascade of reaction generates superoxide anion radical (O 2 ) and hydroxyl radicals (OH) which could be responsible for eradicating bacteria at the wounding site whereas, 2nd cascade reaction alters the wound pH environment from acidic to alkaline by the decomposition of endogenous and exogeneous H 2 O 2 unto O 2 thus eliminates the oxidative stress and hypoxia condition

Different formulations exist because facial skin and body skin have different needs

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Nature Communications 2017;8, 14532, doi:10.1038/ncomms14532