cigarettes make you tired do smoking Why does a sleep-deprived body crave more smoke? What Happens When You Stop

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Because both DNA methylation and hydroxymethylation are regulated by redox reactions [222, 228], it is possible that the elevated burden of oxidative stress imposed by smoking would uniformly impair the one-carbon transfer and the citric acid metabolic pathways that are involved in the formation of 5-mC and 5-hmC, respectively [227]