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Rather, a growing body of evidence suggests that the systemic and local actions of incretins and metabolic hormones modulate multiple pathways that can promote inflammatory and fibrotic injury

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All effects of GLP-1 are exerted by activation of the GLP-1 receptor, a seven transmembrane spanning Gprotein-coupled receptor (GPCR), leading to increased cAMP production and enhanced protein kinase A (PKA) activity