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In cystic fibrosis, a lack of functional CFTR leads to severe mucus stasis/dehydration, inflammation and infection

Prolonged exposure to second-hand smoke can cause airway inflammation, broncho-constriction, airway obstruction and lung tissue damage, increase the likelihood of developing COPD, worsen existing COPD symptoms and accelerate lung function decline [100, 101]

As an avid viewer of The Voice , I dont think theres ever been a coach, in their inaugural season, whos had such a profound impact on the show as a whole