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In sum, SAMe is a key regulator of Met metabolism, and Met concentration is closely related to the level of SAMe ( Figure 2 Figure 3 Met metabolism is closely linked to various metabolic pathways such as folate cycle and transsulfuration pathway ( 3

With lower coordination number complexes packing effects can shift the conformations of flexible ligands but only give rise to very small distortions of the overall coordination geometry

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Both families are complementary, their distinct mechanisms produce a synergy that makes them more effective together