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Histamine exerts multiple activities (see the Biochemistry of Nerve Transmission page) but the two most significant are its roles in immunologic response to antigen and inducing the release of hydrogen ion (H + ) by parietal cells of the stomach to generate the HCl necessary for gastric digestion

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A possible role of glutathione as an endogenous agonist at the N-methyl-D-aspartate recognition domain in rat brain