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Supplementation with high-dose vitamin E (800-1,500 mg/day) is used to prevent neurologic deterioration in AVED subjects

Calcitriol has been shown to enhance autophagic activity in podocytes and tubular cells by restoring LC3-II expression and autophagic flux, while concurrently reducing apoptosis through the modulation of Bcl-2 and Bax expression ( Klotho, an anti-aging factor predominantly expressed in the kidney, is downregulated in CKD and closely linked to vascular dysfunction