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Epigenetic dysregulation plays a central role, involving DNA methylation, histone modifications, and non-coding RNAs

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(4) adipocyte-specific depletion of p53 impedes excessive macrophage abundance under IF and (5) improves the systemic response to fasting, as evident by an increased catabolic state of adipocytes, accelerated body weight loss, improved systemic insulin sensitivity, and enhanced metabolic flexibility of adipocytes

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Documentation is Key: Meticulous record-keeping of dosing protocols, observations, and environmental factors is crucial for data integrity