1 April 2011
While there are some positive results with L-Carnitine supplementation, it must be considered that the overall scientific evidence is lacking
PPAR can upregulate genes involved in fatty acid transport, as well as the fatty acid -oxidation process related to the mitochondria and peroxisomal, to facilitate the intake, utilization, and catabolism of fatty acid (158160), and the mechanism behind this may be an increase in both number and function of mitochondria, leading to a reduction in lipid accumulation (161163)
Variations in cohort characteristicsincluding age, BMI, and ethnic backgroundinconsistent application of diagnostic criteria, and unstandardized intervention protocols such as dose-duration ratios, combination therapies significantly limit the comparability of findings and obscure true effect sizes in existing meta-analyses
Brain Commun 6(1):fcad356 Ribeiro B (2023) Glutathione: the master antioxidant