The unreliable delivery efficiency of systemic administration routes, e.g., intravenous (i.v.) or oral, constitutes another critical bottleneck for lung cancer therapy
Glutathione is a naturally occurring molecule in the body and is generally considered safe for most people
Ligand-Independent EGFR Signaling
Furthermore, ferroptosis is regulated by various processes and small molecules, including iron metabolism, lipid peroxidation (LPO), the XC-GSH-GPX4 axis, ferroptosis suppressor protein 1 (FSP1), coenzyme Q10 (CoQ10)-NAD(P)H pathway, guanosine triphosphate cycloheximide hydrolase 1, tetrahydrobiopterin (BH4)-dihydrofolate reductase pathway, autophagy, mitochondrial function, among others (Chen et al., 2021a
By contrast, Medicinal chemists developed more stable and potent -MSH analogs, including cyclic melanocortin ligands