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Sociodemographic characteristics Diagnosis (vitamin B12 deficiency or pernicious anaemia), age, sex, education level, employment status, country of residence (England, Wales, Scotland, Northern Ireland, Republic of Ireland), region of residence (nine English regions, according to the Office for National Statistics, Wales, Scotland, and Northern Ireland) were assessed using the questions in Supplementary Table S1

Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX2, IL1 , TNF , IL6, and HMGB1 expression