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Chronic pain is the main driver of obesity-related disability, explained by increased mechanical load, low-grade inflammation and consequences of cardiometabolic disease (peripheral neuropathy and claudication) [23]

however, this effect was shown to be more dependent on a combination of subunits as a specific blocker of Kv1.1 failed to improve axonal conduction significantly (Sinha et al., 2006)

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R.Kaminami MorimotoH.LopesJ.et al (2013)