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By analyzing the aortic tissue, we found that FOXO4-DRI treatment significantly increased the expression levels of Ki-67 and Lamin B, while reducing the expression of P21, P16, and -H2AX, similar to the results obtained from naturally aged mice (Figure 2A)

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lvaro-Gracia J, Garca-Llorente J, Valderrama M, Gomez S, Montoro M (2020) Update on the safety profile of tofacitinib in rheumatoid arthritis from clinical trials to real-world studies: a narrative review

It was concluded that rabbits given the combination of AOD 9604 with hyaluronic acid apparently exhibited the least degeneration