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Compared to other peptides studied for anti-aging effects, Epithalon occupies a unique position due to its specific focus on telomerase activation

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In contrast, helix 3 in ironsulfur cluster-binding monothiol glutaredoxins contains a bulky tryptophan residue in a WP-motif that sticks out on the protein surface 3

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PLoS ONE 10:e0125204 Coccurello R, Breysse N, Amalric M (2004) Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats