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As a matter of fact, many disorders like those of the mitochondria (our energy factories within the cell) are, by default, disorders of which the symptoms span many organ systems

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The empty stomach requirement matters because food presence affects gastric pH and transit time

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[5] VLCDs carry recognised risks, including electrolyte imbalances and, in rare cases, QT interval prolongation an abnormality in the heart's electrical cycle that has been reported in association with severe caloric restriction and electrolyte disturbance, and which can predispose individuals to dangerous arrhythmias