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[14] first characterized this cell death by iron dependent lipid peroxidation leading to disrupt membrane properties and shrunken mitochondria

Life Sci 74(19):23392364 Arora DS, Nimitvilai S, Teppen TL, McElvain MA, Sakharkar AJ, You C, Pandey SC, Brodie MS (2013) Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors

Am J Med Genet C Semin Med Genet

The practical implication is that occasional dosing interruptionswhether planned or accidentalshouldn't significantly impact research outcomes in protocols focused on long-term neuroplasticity rather than acute cognitive performance