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[DOI] [PMC free article] [PubMed] [Google Scholar] 715

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Receptor autophosphorylation, downstream phosphorylation of IRS-1 and Shc, and activation of PI3K and MAPK occur with similar kinetics to native IGF-1 once the ligand reaches the receptor

Zhao and Moore, 2018) strikingly reversed that dogma, opening the possibility to employ stem cells as new tools for therapeutic purposes in neural regeneration/repair in diseases and after injuries (Figure 6)

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