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Under normal physiological conditions, CHOP expression remains at a very low level, while in the ERS state, activation of PERK, ATF6, and IRE1 can induce CHOP transcription, significantly increasing its expression and migration into the nucleus, promoting cell apoptosis via the inhibition of BCL-2 protein family (67, 68)

doi: 10.1136/jnnp-2015-312233 76

The persistent secretion of cytokines indicates disruptions in the blood-brain barrier (BBB), resulting in edema and neurological impairments

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Methods of Detecting BPC-157 With Specialized Assays LC-MS/MS Sensitivity and Specificity Liquid chromatographytandem mass spectrometry (LC-MS/MS) is the gold standard for peptide detection in research labs