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3.1 Endothelial dysfunction Various clinical and laboratory studies have shown that endothelial dysfunction induced by cigarette smoke is mediated by decreased nitric oxide (NO) bioavailability, increased production of superoxide anions, and increased production and release of endothelin ( 28 )

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Nicotine can increase your body temperature and your heart rate, which essentially causes your sweat glands to go into overdrive, Lorek explains