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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

Building on these core therapeutic mechanisms, Clostridium -based interventions exhibit clear stratified clinical positioning in ADs, with their therapeutic significance defined by evidence maturity and disease-specific pathological characteristics, serving as a complement rather than a substitute for conventional therapies

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J Cancer Res Clin Oncol (1999) 125(6):321