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In support of this theory, significant changes in pulmonary arterial pressures, the medial thickness of small pulmonary arteries, and right ventricle hypertrophy do not occur until the 3rd or 4th week after monocrotaline exposure [77]

This dual-pathway combination allows investigators to study GLP-1R/GIPR/GCGR triple incretin agonism together with long-acting amylin-pathway modulation in experimental models of energy balance, appetite signaling, and metabolic regulation

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