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[28] Exposure to Gutka tends to be highest in saliva and urine as evaluated by measuring 8-OHdG in DNA

(Source: World Health Organization (WHO)) Health Hazards of Tobacco Consumption Direct Health Impacts: Tobacco use remains a leading cause of preventable death, causing over 8 million deaths annually

Differently, it has been speculated that there is a genetic link that predisposes people with CH to nicotine addiction [7]

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Notably, PS-treated samples exhibited a significant, dose-dependent decrease in the expression of the cdc2 gene, a critical regulator for the G2/M transition in plant cells, consequently hindering mitosis