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However, the pediatric acute liver failure study group has found that in chronic exposure to APAP (in contrast to a single toxic dose), younger patients (median age, 3.5 years) experienced a greater level of hepatotoxicity comparative to older adolescent patients (median age 15.2 years) who were more likely to experience hepatotoxicity from a single toxic dose (Rumack et al., 1981)

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PMID: 20609377 Maes M, Rachayon M, Jirakran K, Sodsai P, Klinchanhom S, Gaecki P, et al

Progressive loss of synaptic integrity in human apoE4 targeted replacement mice and attenuation by apoE2