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Australia was the first country to implement plain packaging in 2012, followed by France and the U.K

The composition of the aerosol depends on the ingredients in the liquid, the electrical characteristics of the heating element, the temperature reached, and the characteristics of the wick.[10] E-cigarette liquids generally consist of glycerol (vegetable glycerin), propylene glycol, and nicotine.[10] In Layden and colleagues case series of persons who vaped and developed EVALI, 60% used a combination of THC and nicotine, 27% used THC alone, and 11% used nicotine alone.[5] Vaping fluids containing THC have been formulated with oils, such as vitamin E acetate, whereas most nicotine-only products are mixed with propylene glycol and glycerin.[11,12] Vitamin E has been implicated in the bronchoalveolar-lavage fluid in EVALI patients.[11] Flavoring agents such as diacetyl, which is commonly found in e-fluids containing nicotine, have been shown to cause bronchiolitis obliterans and other severe respiratory diseases in exposed plant workers.[13] However, even though several large cohort studies were published in 2019, no single constituent was common to all cases

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