Gastroenterology 158 (2), 322340
Endogenous glutathione, glutathione that is produced within the body, is considered the master antioxidant of the human body
Though first discovered as a soluble, periplasmic binding protein (Csp1/Csp2) in methanotrophs and proposed to function in the metalation of pMMO, the cytoplasmic Csp3 is now considered the far more prevalent Csp, and has now been identified in at least ten different bacterial phyla
Accordingly, agents targeting the molecular participants in the Th2-high subtype (e.g., anti-IL-4, anti-IL-5, anti-IL-13, IgE blockers, and inhibitors of prostaglandin D2 (CRTH2) receptor) have recently been presented as potential drugs to treat asthma
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